In pharmaceutical production, several vacuum separation processes are involved, such as rough vacuum recovery and low vacuum recovery of organic solvent, high vacuum distillation of high boiling heat sensitive material, vacuum filtration of solid impurities removal, and vacuum drying of powdery intermediate or products, etc. In all these processes vacuum acquisition equipment are essential- vacuum pumps and vacuum pump units.
Distillation is to separate two or more level or parts which are different in temperature,pressure, composition and morphology. With distillation column balancing, the parts with different concentration can be separated from the mixture. The distillation column provides pressure for separation of different liquid components by changing vacuum degree and temperature. Water ring vacuum device is able to remove noncondensable content, water and light hydrocarbon from the system, and allow raw material to be processed for separation by distilling column. The gas discharged from top distillation column is condensated and the forming liquid returns for further separeation.
They are typical applications in fatty acids, one-component glycerin hydrochloric acid, vitamins (A, E), oil, grease, paraffin wax, pesticides and plasticizer, etc.
Crystallization is the excessive saturated liquid evaporation and cooling to form crystals, which are convenient to carry, storage and sales. For this application,vacuum pumps are ideal choice, they can be used in all pressure to control evaporation and cooling speed, and cut down cost by lowering liquid boiling point.
Degassing is to remove gases which are dissolved or residual in liquid or products. Vacuum device can remove the gas from liquid to improve the physical properties and product quality for further processing, and avoid cross contamination or corrosion, eg, oil degassing to improve purity (hydrocarbon oil, insulating oil, turbine oil, brake fluid and hydraulic brake oil, etc.),paste and paint degassing to remove excess gas that may harden or lower quality, polymer degassing in extruder, in order to get higher quality products or bubbleless.
Drying is a low cost and low temperature procedure. It evaporates liquid from the solids by reducing vacuum degree, and biological ingredients or active ingredients are not damaged, effect falling or oxidation. Drying of medical and biological products,including removing solvent and water etc., asks for high degree of the final drying device. The Roots pump units which are excellent in vacuum degree are recommended( see the right picture). We recommend the use of water ring vacuum degree higher unit (e.g., right). After drying, granular products are left and then pressed into tablets, with low damp and keep longer.
Central vacuum system aspirates medical sputum from ward, operating room, emergency room, therapy room to aspiration station, and then disinfects and discharges. It mainly includes central aspiration station, vacuum pipes and end aspiration devices. Central aspiration station is the key part which is composed of vacuum pump, buffer tank, valves and control instruments. The vacuum pump produces negative pressure to aspirate the medical sputum from sickroom, operating room, emergency room and therapy room into vacuum buffer tank and disinfects and discharges.